Researchers at Flinders are taking aim at the most aberrant and drug resistant tumours by identifying novel targets for metabolic therapy to kill cancer cells with chromosomal instability.

Using a Health Seed Grant from Flinders Foundation, Dr Stephen Gregory will look for new ways to target cancer cells in less harmful ways than current chemotherapy treatments.

He’ll do this by screening for new chemicals that can specifically target cells with chromosomal instability, which it’s hoped will be particularly effective against those tumours which are hardest to treat.

Some level of chromosomal instability is present in most cancers, however this work will be particularly relevant to colorectal cancer which has high rates of chromosomal instability.

With current chemotherapy treatment often limited by toxicity and drug resistance, researchers are striving to find new ways to overcome these limitations and improve treatment.

This research is made possible thanks to generous support from the community and our partners Mr Riggs Wine Company, Foodland and Bay to Birdwood.

Project title: Identifying novel targets for metabolic therapy to kill cancer cells with chromosomal instability.

Lead researcher: Dr Stephen Gregory